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Bone marrow trephine biopsy section, B-CLL, diffuse infiltration. Bone marrow trephine biopsy section, B-CLL, nodular infiltration.
Bcl-x expression in infiltration cells before tion cells from The results are presented in Table 1. After the treatment percentage Correlation between Bcl-2 expression and the stage of value of the infiltration cells with positive anti-Bcl-x lymphoid infiltration before and after treatment was reaction was accounted for Bax expression in infiltration cells was After the treatment percentage value of the stage of infiltration was found.
There The higher the ratio tion cells with Bcl-2 was observed before treatment is, the worse prognosis of achieving total remission of Fig. In case of increased values of in eleven patients.
Our studies revealed reaction with anti Bcl-2 in ten patients, whereas with correlation between Bcl-2 and Bax proteins before Bax in thirteen patients Fig. In thirteen patients treatment. In other cases the intensi- those patients. Bcl-2 and Bax correlation was not con- ty of the positive reaction was moderate. In single firmed after treatment. It has been suggested that neoplastic cells seem to Differences between the intensity stage of immunohis- have disturbed mechanism of apoptosis due to Bcl-xL tochemical reaction of infiltration cells with Bcl-2, protein [2,3].
In our studies polyclonal antibody Bcl-x Bax and Bcl-x before and after the treatment that was used. Correlation between Bcl-x and the stage of appeared were not statistically significant. Bcl-2 protein plays a key role in the is a sensitive marker of MRD in bone marrow [18].
In control of apoptosis [2]. Correlation ports the possibility of performing tests on expression between the percentage of lymphoid cells and expres- of Bcl-2 family proteins in trephine biopsy specimens sion of Bcl-2 protein was shown. This supports obser- of bone marrow.
Bone marrow examination through vations, that excessive expression of this protein is one TB with the help of immunohistochemical methods of the most important factors in the development of and image analysis supports its usefulness in progno- many neoplasms, including CLL. It is also significant sis of the course of the disease, assessment of effica- in the case of survival of neoplastic cells [6]. Exces- cy of the administered treatment and MRD detection sive expression of anti-apoptotic Bcl-2 family proteins [11,12,18].
In most cases of our study it turned out References that despite the administered treatment and change of the infiltration pattern from diffuse into nodular, the [ 1] Granziero L, Ghia P, Circosta P et al. Survivin in expressed on expression of Bcl-2 protein was still observed.
This CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic leukemia. Cell cycle dereg- nism of apoptosis and excessive Bcl-2 expression were ulation in B-cell lymphomas.
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